Data-driven technology and Artificial Intelligence (AI) are set to revolutionise the health sector, driving transformation in virtually all public health areas, from diagnostics, to screening, treatment and beyond. Big data, digital tech and AI may contribute to the fulfilment of social rights, serving as a critical tool to enable social mobilisation and identify health disparities, discrimination and inaccessibility. However, the way data, AI and technology are used in global health raises important questions about human rights including how rights can be ensured during the digital wave. These important questions underpin a special section in the December 2020 issue of the Health and Human Rights Journal. In this roundtable, the contributing editors and authors will take up these questions, including in relationship to the Black Lives Matter movement and the present pandemic.